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Pat Smallcombe

Pat Smallcombe

CEO
Metagenics
20 January 2025

Pat, you spent the best part of three decades in the pharmaceutical industry. Having moved into nutraceuticals, why does Metagenics stand out to you in this space?

Metagenics has a unique story. Founded in 1983, it was one of the pioneers of functional medicine in the United States. It is built on credible science and exceptional product quality - vital for delivering great healthcare.

At Metagenics, we conduct clinical trials similar to those in pharma, including double-blind, placebo-controlled studies and go beyond ingredient-level claims by validating our entire formulations. 

Secondly, it is a global brand, manufacturing in the U.S., Australia and Europe, with a smaller but rapidly expanding business in China. Combined, that global presence and level of scientific rigor allows us to gather valuable healthcare insights from various regions and adapt to different market needs and consumer behaviors. As a leader in science-backed nutrition, our challenge then is to democratize functional medicine. 

What are the focus areas in Metagenics’ product portfolio?

At Metagenics, we focus on addressing specific health needs with targeted products. Our key focus areas include gut health, stress and sleep, women’s health, and naturopathic pain management—areas where we can make a significant impact.

For example, gut health is central to overall wellness, and many people struggle with stress and sleep in today’s fast-paced world. Women’s health is another priority, addressing the challenges of various life stages. Finally, we aim to provide alternatives for pain management that are gentler than traditional pharmaceuticals but still effective. By offering self-diagnosable solutions, we make it easier for people to access the benefits of personalized nutrition.

How does the demand for different types of nutrition products vary between global regions?

The underlying health challenges are consistent globally, but how people approach treatment varies. For example, probiotics are a significant category in North America and Australia but less mature in Europe, where consumers are still learning about their benefits. 

Similarly, gut health is more prominent in the U.S. and Australia, while women’s health is more developed in the U.S. and emerging in Europe and Australia. These differences reflect varying levels of consumer awareness and understanding of available solutions. We adapt our approach to meet consumers where they are on this continuum, changing our strategies to fit local needs.

What kinds of external R&D collaborations enable product innovation at Metagenics?

We collaborate extensively with universities and other institutions. For example, we have a close relationship with Harvard Business School, which helped us develop our SPM product for muscle soreness and pain. Additionally, we work with the Cleveland Clinic, diabetes organizations, and universities like KU Leuven in Belgium and institutions in Australia. 

How do you approach educating healthcare practitioners and consumers, given that health and nutrition is such a crowded knowledge space?

We conduct extensive clinical and real-world evidence studies to validate our products and share insights like, "800 patients used this product, and 87% experienced benefits within four weeks," which are more relatable than complex clinical papers. Our goal is to empower doctors to share these benefits with their patients by making the science behind our products accessible and actionable. For consumers who want to know more, we have a TruQuality program. They can look up the batch number on their product and access detailed information on its ingredients through our website.

We also sponsor the Metagenics Institute, which operates independently from Metagenics and is a vital educational tool. It serves as a repository for the latest clinical information in functional medicine, offering webinars, research, and insights from key opinion leaders on therapeutic areas and ingredients. For example, practitioners can learn about how magnesium or curcumin may help with specific conditions. By focusing on the science behind our products, the Institute helps practitioners deepen their understanding of functional medicine. 

What is Metagenics’ strategy for entering the Chinese market, and how is that progressing?

We employ two key strategies for entering the Chinese market. The first is cross-border e-commerce, where products sold in Australia are made available to Chinese consumers through platforms like Tmall. This model involves digital advertising both on and off these platforms. The second strategy involves partnering with distributors to supply healthcare professionals and institutions like cellular health hospitals in China, where our products are recommended to patients undergoing treatments.

These approaches allow us to navigate China’s regulatory environment. For broader pharmacy distribution, we would require a Blue Hat regulatory approval, which is a lengthy and complex process. Despite these challenges, our business in China is growing rapidly, with 100% growth currently, and we anticipate this momentum continuing.

Which market trends will Metagenics leverage in 2025?

We see significant growth opportunities in areas like stress, sleep, and gut health—trends that are prominent globally. The professional nutritional category is experiencing remarkable growth, particularly on platforms like Amazon, where it is growing at 35% compared to the general VMS category’s 3%. Consumers increasingly seek products recommended by doctors, valuing their efficacy and quality even at a higher price point.