Content Provider for Newsweek
Darin J. Messina Ph.D

Darin J. Messina Ph.D

Senior Vice President - Aesthetics R&D
Allergan Aesthetics / AbbVie
21 May 2024

Can you provide a general introduction to Allergan Aesthetics and your operations in the aesthetics area?

Allergan Aesthetics, a market leader in the aesthetic space, is known for its leading products across various franchises, including neurotoxins, dermal and soft tissue fillers, non-invasive body contouring, plastic surgery and regenerative medicine, and topical skincare. Acquired by AbbVie four years ago, Allergan Aesthetics became a wholly owned subsidiary, marking our integration into the AbbVie community. My journey with Allergan Aesthetics, now AbbVie, spans nearly 14 years, starting in the medical devices division. Throughout this time, we've significantly grown through acquisitions and integrations, where I've taken the role of the senior vice president and global head of Allergan Aesthetics R&D, emphasizing innovation and leadership in the aesthetic medicine field.

How do you select the aesthetic technologies and products you focus on?

Our selection is heavily based on science-backed products that are differentiated by their innovative technology, leading to optimal patient outcomes with a strong safety profile.

Despite common misconceptions, the aesthetic field is deeply rooted in science, not merely vanity. We prioritize technologies that address unmet needs within the aesthetic space, ensuring our offerings stand out for their safety and effectiveness.

This approach allows us to maintain our leadership by providing top-notch technologies that meet the specific, and often critical, requirements of aesthetic medicine.

Could you share insights on the non-aesthetic uses of Botox and its importance?

Botox, well-known for its aesthetic applications, also has several therapeutic indications, such as treating upper limb spasticity and chronic migraines, showcasing its versatility. While I oversee the aesthetic side, including treatments to temporarily improve the look of forehead lines, crow’s feet lines, and frown lines between the eyebrows in adults, Botox's therapeutic applications highlight its significant impact beyond aesthetics. Its ability to temporarily relax muscles has been a game-changer for patients, demonstrating Botox's utility in addressing a range of medical conditions effectively.

Our ongoing development efforts aim to expand Botox's indications, ensuring its safety profile supports its use in new therapeutic and aesthetic applications. This exemplifies our commitment to exploring the full potential of our products to address a wide range of needs.

What exciting developments can you share about Allergan Aesthetics' product pipeline?

With the largest investment in our industry, Allergan Aesthetics boasts over 60 pipeline programs globally, driven by a diverse team of experts. We're excited about breakthroughs like BoNT/E, a novel botulinum neurotoxin serotype E , offering early onset and rapid action, aimed at attracting those curious about aesthetic treatments. Our focus extends to next-generation toxins and addressing aging's underlying causes through innovative products in filler, plastic surgery, and regenerative medicine spaces, aiming to restore youthful tissue and address significant unmet needs.

How does your background in stem cells and regenerative biomaterials influence your work?

My background in stem cells and regenerative biomaterials aligns with Allergan Aesthetics' efforts to address tissue disease and dysfunction, particularly in aging. By focusing on stem cells, biomaterials, and growth factors, we aim to restore tissue function through regenerative cues, enabling our body's stem cells to rebuild damaged tissues. This approach is pivotal in both aesthetic and therapeutic applications, showcasing our commitment to innovation in regenerative medicine.

How do you view the current trend towards addressing aging and its impact on Allergan Aesthetics?

The trend towards addressing aging through various means, including diet, sun protection, and longevity drugs, intersects with our work in aesthetics. Our products contribute to this broader movement by focusing on local tissue aging, offering treatments that restore tissue function or create a more youthful appearance at the site of treatment. This local approach complements systemic interventions, positioning Allergan Aesthetics as a key player in the evolving landscape of age management.

How does Allergan ensure the safety of its aesthetic products?

Patient safety and product quality are foundational to our operations. Our commitment is demonstrated through rigorous safety outcomes, quality ingredients, and superior manufacturing processes. By leveraging AbbVie's extensive quality and manufacturing infrastructure, we ensure that only the highest quality products reach the market. Our approach to safety is comprehensive, encompassing healthcare provider education and adherence to stringent pharmaceutical and medical device standards, underscoring our dedication to leading with safe, effective products.

What is your vision for the future of Allergan Aesthetics?

Looking ahead, Allergan Aesthetics aims to empower confidence by evolving consumer perceptions from vanity towards quality of life and youthful aging. Our mission guides us to develop differentiated products with meaningful impacts and strong safety profiles. We envision a future where multimodal treatments offer personalized, optimal outcomes, driven by innovation against unmet needs like skin quality. As the market leader, we bear the responsibility to lead in safety and innovation, shaping the future of aesthetics to enhance individuals' lives meaningfully.

Can you share a story that highlights the impact of your products on individuals?

One of the most impactful stories comes from our work in breast reconstruction, where medical device implants significantly improve psychological well-being for individuals undergoing mastectomy. Witnessing the transformative power of our products on individuals' confidence and societal re-engagement post-surgery is profoundly rewarding. It exemplifies our broader impact beyond aesthetics, demonstrating our commitment to enhancing lives through confidence-boosting solutions.